FORMULASI NANOSUSPENSI EKSTRAK KERING RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) DENGAN METODE GELASI IONIK DAN UJI AKTIVITAS ANTIOKSIDAN
نویسندگان
چکیده
Temulawak (Curcuma xanthorhiza Roxb.) mengandung kurkumin berkhasiat sebagai antioksidan. Rendahnya kelarutan, ketersediaan hayati dan stabilitas menjadi kendala untuk dikembangkan sediaan oral. Tujuan penelitian adalah memformulasi ekstrak kering nanosuspensi antioksidan dengan metode gelasi ionik. Dilakukan optimasi terhadap empat formula yang konsentrasi sebesar : 100-700 x IC50. Penetapan optimum dari ke-empat berdasarkan: stabilitas, ukuran partikel indeks polidispersitas. Formula dikarakterisasi meliputi: morfologi, potensial zeta, efisiensi penjerapan aktivitas DPPH. 100 IC50 paling stabil, 300,4 nm polidispersitas 0,292 ditetapkan optimum. Hasil karakterisasi optimum: zeta +47,7; 63,49% IC50, 30,22 bpj. Ekstrak dapat diformulasikan berpotensi
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ژورنال
عنوان ژورنال: Jurnal Farmamedika (Pharmamedica Journal)
سال: 2022
ISSN: ['2686-4487', '2502-6011']
DOI: https://doi.org/10.47219/ath.v7i2.163